Prednisone is a common synthetic corticosteroid medication that was initially synthesized in 1955. Upon ingestion of prednisone, it doesn’t elicit significant biological effects until converted via the liver to the pharmacologically active chemical “prednisolone.” Find patient medical information for Prednisone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. How long does prednisone stay in your system after stopping? (Prednisone half-life) To accurately estimate how long prednisone will remain in your body after stopping, you must know its elimination half-life and the half-life of its active metabolite “prednisolone.” Precautions. Drug information provided by: IBM Micromedex. If you will be taking this medicine for a long time, it is very important that your doctor check you at regular visits for any unwanted effects that may be caused by this medicine. Prednisone is a prescription drug that is used to help decrease inflammation and suppress an overactive immune system. The medication comes in either liquid or tablet form and is taken just once a day or several times a day, depending on the condition being treated. The elimination half life of prednisone is around 3 to 4 hours. This is the time it takes for your body to reduce the plasma levels by half. It usually takes around 5.5 half lives for a drug to be completely eliminated from your system. I was given prednisone to comabt an allergic hive reaction to an antibiotic. Turns out I was also allergic to prednisone but the doctors kept refusing to believe that was the case and one even prescribed an increased dose of prednisone. How long does it take once you stop Prednisone for the side effects to go away? I feel like I've been hit by a truck. It's a very strange pain that I have in my hips, my shoulders, and my neck. Prednisone (Prednisone Intensol, Rayos) is a drug used for suppressing the immune system and inflammation such as asthma, severe psoriasis, lupus, ulcerative colitis, Crohn's disease, and several types of arthritis. Side effects, drug interactions, dosage, and pregnancy and breastfeeding safety information are provided. Prednisone is a glucocorticoid medication mostly used to suppress the immune system and decrease inflammation in conditions such as asthma, COPD, and rheumatologic diseases. It is also used to treat high blood calcium due to cancer and adrenal insufficiency along with other steroids. It is taken by mouth.